Aldehyde Dehydrogenase (ALDH)

By Targets:	Aldehyde Dehydrogenase (ALDH) (19) Apoptosis (1) Cuproptosis (1) Interleukin Related (1) Pyroptosis (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Metabolic Disease (5)

Targets Recommended: Aldehyde Dehydrogenase (ALDH) Succinate Dehydrogenase Lactate Dehydrogenase Dihydroorotate Dehydrogenase Isocitrate Dehydrogenase (IDH) Methylenetetrahydrofolate Dehydrogenase (MTHFD) Phosphoglycerate Dehydrogenase (PHGDH) PDHK 15-PGDH 17β-HSD 11β-HSD

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2947

ALDH Aldehyde Dehydrogenase (NAD(P))	Aldehyde Dehydrogenase (ALDH)	Others
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .

HY-126003

ALDH1A1-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295) .

HY-19801

CVT-10216 1 Publications Verification
CVT-10216 is a highly selective, reversible **aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC₅₀** of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC₅₀ of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects .

HY-148617

ALDH2 modulator 1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH2 modulator 1 is a potent and orally active **aldehyde dehydrogenase-2 (ALDH2)** modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice .

HY-157872

ALDH1A1-IN-4	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, with IC₅₀ value of 0.32 μM. ALDH1A1-IN-4 plays an important role in cancer research .

HY-112278

NCT-506

Aldehyde Dehydrogenase (ALDH) Cancer

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC₅₀ of 7 nM .

NCT-506	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC₅₀ of 7 nM .

HY-107030

Nitrefazole EMD-15700	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Nitrefazole is a 4-nitroimidazole derivative with strong and long lasting inhibition of **aldehyde dehydrogenase (ALDH)**, an enzyme involved in the metabolism of alcohol.

HY-110294

CM037

A37
Aldehyde Dehydrogenase (ALDH) Cancer

CM037 is a selective inhibitor of ALDH1A1 (aldehyde dehydrogenase 1A1) with an IC₅₀ of 4.6 µM .

CM037 A37	Aldehyde Dehydrogenase (ALDH)	Cancer
CM037 is a selective inhibitor of *ALDH1A1* (aldehyde dehydrogenase 1A1) with an IC₅₀ of 4.6 µM .

HY-144671

ALDH3A1-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH3A1-IN-2 (Compound 19) is a potent inhibitor of *ALDH3A1* with an IC₅₀ of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH3A1-IN-2 has the potential for the research of cancer diseases .

HY-144669

ALDH1A3-IN-2	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A3-IN-2 (Compound 15) is a potent inhibitor of *ALDH1A3* with an IC₅₀ of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH1A3-IN-2 has the potential for the research of cancer diseases .

HY-W016645

4-Diethylaminobenzaldehyde 1 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Cancer
4-Diethylaminobenzaldehyde is a reversible **aldehyde dehydrogenases (ALDHs) inhibitor, with a K_i** of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC₅₀= 1.71μM) .

HY-158026

ALDH1A1-IN-5	Aldehyde Dehydrogenase (ALDH)	Cancer
ALDH1A1-IN-5 (compound 25) is a potent **aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC₅₀** value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC) .

HY-122577

EN40

Aldehyde Dehydrogenase (ALDH) Cancer

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC₅₀ value of 2 uM

EN40	Aldehyde Dehydrogenase (ALDH)	Cancer
EN40 is a potent, selective **aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC₅₀** value of 2 uM

HY-135841

CM10	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease Cancer
CM10 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC₅₀s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity .

HY-146240

ALDH1A1-IN-3	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
ALDH1A1-IN-3 (compound 57) is an excellent and selective **aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC₅₀** value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement .

HY-76006

3-Hydroxybenzaldehyde M-HydroxybenzAldehyde	Aldehyde Dehydrogenase (ALDH)	Cardiovascular Disease
3-Hydroxybenzaldehyde is a precursor compound for phenolic compounds, such as Protocatechualdehyde (HY-N0295). 3-Hydroxybenzaldehyde is a substrate of **aldehyde dehydrogenase (ALDH)** in rats and humans (ALDH2). 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo .

HY-18768

NCT-501 4 Publications Verification	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 is a potent and selective theophylline-based inhibitor of **aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀** of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM).

HY-18768A

NCT-501 hydrochloride	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of **aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC₅₀** of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC₅₀ >57 μM) .

HY-112277

NCT-505	Aldehyde Dehydrogenase (ALDH)	Cancer
NCT-505 is a potent and selective **aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC₅₀ of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC₅₀**s, >57, 22.8, 20.1, >57 μM).

HY-B0240

Disulfiram Maximum Cited Publications 47 Publications Verification Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase *(ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD)* pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

Cat. No.	Product Name	Type

HY-P2947

ALDH Aldehyde Dehydrogenase (NAD(P))	Biochemical Assay Reagents
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-76006

3-Hydroxybenzaldehyde M-HydroxybenzAldehyde	Cardiovascular Disease Structural Classification Monophenols other families Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields	Aldehyde Dehydrogenase (ALDH)
3-Hydroxybenzaldehyde is a precursor compound for phenolic compounds, such as Protocatechualdehyde (HY-N0295). 3-Hydroxybenzaldehyde is a substrate of **aldehyde dehydrogenase (ALDH)** in rats and humans (ALDH2). 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo .

Species:	Human (6)
Tag:	His (6)
Source:	HEK293 (1) Sf9 insect cells (1) P. pastoris (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P75568

	ALDH3A1 Protein, Human (sf9, His) Aldehyde Dehydrogenase, dimeric NADP-preferring; Aldehyde Dehydrogenase 3 member A1; ALDHIII; ALDH3	Human	Sf9 insect cells
	The ALDH3A1 protein is critical for acetaldehyde detoxification in alcohol metabolism, oxidizing medium- and long-chain aldehydes to nontoxic fatty acids. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. ALDH3A1 Protein, Human (sf9, His) is the recombinant human-derived ALDH3A1 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of ALDH3A1 Protein, Human (sf9, His) is 453 a.a., with molecular weight of ~50 kDa.

HY-P7474

	ALDH1A1 Protein, Human (His) rHuAldehyde Dehydrogenase 1-A1, His; ALDH-1A1; Aldehyde Dehydrogenase 1-A1	Human	E. coli
	ALDH1A1 Protein, Human (His) is a human recombinant ALDH1A1 with an N-terminal Met and His tag produced in E. coli. ALDH1A1 Protein, Human (His) contains 501 amino acids (1-501 a.a.).

HY-P7475

	ALDH1A2 Protein, Human (His) rHuAldehyde Dehydrogenase 1-A2, His ; ALDH-1A2; Aldehyde Dehydrogenase 1-A2	Human	E. coli
	ALDH1A2 Protein, Human (His) is a human recombinant ALDH1A2 with a N-terminal His tag produced in E. coli. ALDH1A2 Protein, Human (His) expresses the target gene encoding Met1-Ser518.

HY-P7476

	ALDH1A3 Protein, Human (His) rHuAldehyde Dehydrogenase 1-A3, His; ALDH-1A3; Aldehyde Dehydrogenase 1-A3	Human	E. coli
	ALDH1A3 Protein, Human (His) is a human recombinant ALDH1A3 with a His tag at the N-terminus. ALDH1A3 Protein, Human (His) is produced in E. coli and the target gene encoding Met1-Pro512 is expressed.

HY-P700646

	ALDH1A2 Protein, Human (P.pastoris, His) rHuAldehyde Dehydrogenase 1-A2, His ; ALDH-1A2; Aldehyde Dehydrogenase 1-A2	Human	P. pastoris
	The ALDH1A2 protein catalyzes the NAD-dependent oxidation of aldehyde substrates, including all-trans -retinal and all-trans 13,14-dihydroretinal. ALDH1A2 Protein, Human (P.pastoris, His) is the recombinant human-derived ALDH1A2 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of ALDH1A2 Protein, Human (P.pastoris, His) is 518 a.a., with molecular weight of 58.7 kDa.

HY-P7477

	ALDH3A1 Protein, Human (HEK293, His) rHuAldehyde Dehydrogenase family 3 member A1, His; ALDH-3A1; Aldehyde Dehydrogenase 3 member A1	Human	HEK293
	ALDH3A1 Protein, Human (HEK293, His) is a human recombinant ALDH3A1 with a His tag at the N-terminus. ALDH3A1 Protein, Human (HEK293, His) is expressed in HEK293 cells.


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Cat. No.	Product Name	Application	Reactivity

HY-P81326

ALDH3A2 Antibody (YA1071) ALDH3A2; ALDH10; FALDH; Fatty Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 10; Aldehyde Dehydrogenase family 3 member A2; Microsomal Aldehyde Dehydrogenase	WB	Human

HY-P80536

ALDH1A1 Antibody ALDH1A1; ALDC; ALDH1; PUMB1; Retinal Dehydrogenase 1; RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde Dehydrogenase family 1 member A1; Aldehyde Dehydrogenase; cytosolic	WB, IHC-P, IP	Human, Mouse
ALDH1A1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 55 kDa, targeting to ALDH1A1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse.

HY-P81375

ALDH3A1 Antibody (YA1120)

Aldehyde Dehydrogenase 3 family; member A1; ALDH3; ALDHIII
IHC-P Human
HY-P81257

ALDH2 Antibody (YA928)

ALDH2; ALDM; Aldehyde Dehydrogenase; mitochondrial; ALDH class 2; ALDH-E2; ALDHI
WB Human, Mouse, Rat, Monkey, Hamster
HY-P81257A

ALDH2 Antibody (YA929)

ALDH2; ALDM; Aldehyde Dehydrogenase; mitochondrial; ALDH class 2; ALDH-E2; ALDHI
WB, IHC-P, IP Human, Mouse
HY-P82289

ALDH7A1 Antibody (YA2034)

Aldehyde Dehydrogenase 7 family member A1; EPD; PDE; ATQ1
WB, ICC/IF, IP Human, Mouse

HY-P81724

ALDH1A2 Antibody (YA1469) ALDH1A2; RALDH2; Retinal Dehydrogenase 2; RALDH 2; RalDH2; Aldehyde Dehydrogenase family 1 member A2; RetinAldehyde-specific Dehydrogenase type 2; RALDH(II)	WB	Human, Mouse, Rat

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Aldehyde Dehydrogenase (ALDH)

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